3,294 research outputs found
The Two Phases of Galaxy Formation
Cosmological simulations of galaxy formation appear to show a two-phase
character with a rapid early phase at z>2 during which in-situ stars are formed
within the galaxy from infalling cold gas followed by an extended phase since
z<3 during which ex-situ stars are primarily accreted. In the latter phase
massive systems grow considerably in mass and radius by accretion of smaller
satellite stellar systems formed at quite early times (z>3) outside of the
virial radius of the forming central galaxy. These tentative conclusions are
obtained from high resolution re-simulations of 39 individual galaxies in a
full cosmological context with present-day virial halo masses ranging from 7e11
M_sun h^-1 < M_vir < 2.7e13 M_sun h^-1 and central galaxy masses between 4.5e10
M_sun h^-1 < M_* < 3.6e11 M_sun h^-1. The simulations include the effects of a
uniform UV background, radiative cooling, star formation and energetic feedback
from SNII. The importance of stellar accretion increases with galaxy mass and
towards lower redshift. In our simulations lower mass galaxies (M_* > 1.7e11 M_sun h^-1) assembly is dominated by accretion and
merging with about 80 per cent of the stars added by the present-day. In
general the simulated galaxies approximately double their mass since z=1. For
massive systems this mass growth is not accompanied by significant star
formation. The majority of the in-situ created stars is formed at z>2,
primarily out of cold gas flows. We recover the observational result of
archaeological downsizing, where the most massive galaxies harbor the oldest
stars. We find that this is not in contradiction with hierarchical structure
formation. Most stars in the massive galaxies are formed early on in smaller
structures, the galaxies themselves are assembled late.Comment: 13 pages, 13 figures, accepted for publication in Ap
Can Cascades be Predicted?
On many social networking web sites such as Facebook and Twitter, resharing
or reposting functionality allows users to share others' content with their own
friends or followers. As content is reshared from user to user, large cascades
of reshares can form. While a growing body of research has focused on analyzing
and characterizing such cascades, a recent, parallel line of work has argued
that the future trajectory of a cascade may be inherently unpredictable. In
this work, we develop a framework for addressing cascade prediction problems.
On a large sample of photo reshare cascades on Facebook, we find strong
performance in predicting whether a cascade will continue to grow in the
future. We find that the relative growth of a cascade becomes more predictable
as we observe more of its reshares, that temporal and structural features are
key predictors of cascade size, and that initially, breadth, rather than depth
in a cascade is a better indicator of larger cascades. This prediction
performance is robust in the sense that multiple distinct classes of features
all achieve similar performance. We also discover that temporal features are
predictive of a cascade's eventual shape. Observing independent cascades of the
same content, we find that while these cascades differ greatly in size, we are
still able to predict which ends up the largest
Latent Space Model for Multi-Modal Social Data
With the emergence of social networking services, researchers enjoy the
increasing availability of large-scale heterogenous datasets capturing online
user interactions and behaviors. Traditional analysis of techno-social systems
data has focused mainly on describing either the dynamics of social
interactions, or the attributes and behaviors of the users. However,
overwhelming empirical evidence suggests that the two dimensions affect one
another, and therefore they should be jointly modeled and analyzed in a
multi-modal framework. The benefits of such an approach include the ability to
build better predictive models, leveraging social network information as well
as user behavioral signals. To this purpose, here we propose the Constrained
Latent Space Model (CLSM), a generalized framework that combines Mixed
Membership Stochastic Blockmodels (MMSB) and Latent Dirichlet Allocation (LDA)
incorporating a constraint that forces the latent space to concurrently
describe the multiple data modalities. We derive an efficient inference
algorithm based on Variational Expectation Maximization that has a
computational cost linear in the size of the network, thus making it feasible
to analyze massive social datasets. We validate the proposed framework on two
problems: prediction of social interactions from user attributes and behaviors,
and behavior prediction exploiting network information. We perform experiments
with a variety of multi-modal social systems, spanning location-based social
networks (Gowalla), social media services (Instagram, Orkut), e-commerce and
review sites (Amazon, Ciao), and finally citation networks (Cora). The results
indicate significant improvement in prediction accuracy over state of the art
methods, and demonstrate the flexibility of the proposed approach for
addressing a variety of different learning problems commonly occurring with
multi-modal social data.Comment: 12 pages, 7 figures, 2 table
Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV):use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3
The effect of sequence variability between different types of hepatitis C virus (HCV) on the antigenicity of the NS-4 protein was investigated by epitope mapping and by enzyme-linked immunosorbent assay with branched oligopeptides. Epitope mapping of the region between amino acid residues 1679 and 1768 in the HCV polyprotein revealed two major antigenic regions (1961 to 1708 and 1710 to 1728) that were recognized by antibody elicited upon natural infection of HCV. The antigenic regions were highly variable between variants of HCV, with only 50 to 60% amino acid sequence similarity between types 1, 2, and 3. Although limited serological cross-reactivity between HCV types was detected between peptides, particularly in the first antigenic region of NS-4, type-specific reactivity formed the principal component of the natural humoral immune response to NS-4. Type-specific antibody to particular HCV types was detected in 89% of the samples from anti-HCV-positive blood donors and correlated almost exactly with genotypic analysis of HCV sequences amplified from the samples by polymerase chain reaction. Whereas almost all blood donors appeared to be infected with a single virus type (97%), a higher proportion of samples (40%) from hemophiliacs infected from transfusion of non-heat-inactivated clotting factor contained antibody to two or even all three HCV types, providing evidence that long-term exposure may lead to multiple infection with different variants of HCV
Cascades: A view from Audience
Cascades on online networks have been a popular subject of study in the past
decade, and there is a considerable literature on phenomena such as diffusion
mechanisms, virality, cascade prediction, and peer network effects. However, a
basic question has received comparatively little attention: how desirable are
cascades on a social media platform from the point of view of users? While
versions of this question have been considered from the perspective of the
producers of cascades, any answer to this question must also take into account
the effect of cascades on their audience. In this work, we seek to fill this
gap by providing a consumer perspective of cascade.
Users on online networks play the dual role of producers and consumers.
First, we perform an empirical study of the interaction of Twitter users with
retweet cascades. We measure how often users observe retweets in their home
timeline, and observe a phenomenon that we term the "Impressions Paradox": the
share of impressions for cascades of size k decays much slower than frequency
of cascades of size k. Thus, the audience for cascades can be quite large even
for rare large cascades. We also measure audience engagement with retweet
cascades in comparison to non-retweeted content. Our results show that cascades
often rival or exceed organic content in engagement received per impression.
This result is perhaps surprising in that consumers didn't opt in to see tweets
from these authors. Furthermore, although cascading content is widely popular,
one would expect it to eventually reach parts of the audience that may not be
interested in the content. Motivated by our findings, we posit a theoretical
model that focuses on the effect of cascades on the audience. Our results on
this model highlight the balance between retweeting as a high-quality content
selection mechanism and the role of network users in filtering irrelevant
content
Life interrupted and life regained? Coping with stroke at a young age
Stroke is a leading cause of disability across the developed world, affecting an increasing number of younger people. In this article, we seek to understand the experience of stroke as a disabling life situation among young people and the strategies that they use to recover and cope. Directed content analysis was conducted from interviews with 17 community-dwelling stroke survivors aged 55 years and younger across the United Kingdom. The sample was drawn from a larger maximum variation sample of stroke survivors. Using the sociological concepts of biographical disruption and biographical repair as a guide, excerpts from the interviews pertaining to aspects of the patients’ life that were interrupted, in addition to how they coped with the changes, were selected and analysed. All individuals described an ‘‘altered sense of self,’’ a theme that included loss of identity, family disruption, and/or loss of valued activities. Individuals sought to adapt their sense of self by seeking external support, by restoring normality, and/or through positive reflection. Despite the adapted self that emerged, most individuals continued to experience impairments. While young stroke survivors adapt to their illness over time, they continue to experience impairments and disruptions in their personal and work lives.Aholistic model of rehabilitation that helps individuals regain the capacity for everyday activities related to work, family life, and leisure can begin to address the emotional ramifications of diseases such as stroke, restore wellness, and work towards minimizing the burden felt by family caregivers and children
SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia
Loss of cellular polarity is a hallmark of epithelial cancers, raising the possibility that regulators of polarity have a role in suppressing tumorigenesis. The Scribble complex is one of at least three interacting protein complexes that have a critical role in establishing and maintaining epithelial polarity. In human colorectal, breast, and endometrial cancers, expression of the Scribble complex member SCRIB is often mislocalized and deregulated. Here, we report that Scrib is indispensable for prostate homeostasis in mice. Scrib heterozygosity initiated prostate hyperplasia, while targeted biallelic Scrib loss predisposed mice to prostate intraepithelial neoplasia. Mechanistically, Scrib was shown to negatively regulate the MAPK cascade to suppress tumorigenesis. Further analysis revealed that prostate-specific loss of Scrib in mice combined with expression of an oncogenic Kras mutation promoted the progression of prostate cancer that recapitulated the human disease. The clinical significance of the work in mice was highlighted by our observation that SCRIB deregulation strongly correlated with poor survival in human prostate cancer. These data suggest that the polarity network could provide a new avenue for therapeutic intervention
Life interrupted and life regained? Coping with stroke at a young age
Stroke is a leading cause of disability across the developed world, affecting an increasing number of younger people. In this article, we seek to understand the experience of stroke as a disabling life situation among young people and the strategies that they use to recover and cope. Directed content analysis was conducted from interviews with 17 community-dwelling stroke survivors aged 55 years and younger across the United Kingdom. The sample was drawn from a larger maximum variation sample of stroke survivors. Using the sociological concepts of biographical disruption and biographical repair as a guide, excerpts from the interviews pertaining to aspects of the patients’ life that were interrupted, in addition to how they coped with the changes, were selected and analysed. All individuals described an ‘‘altered sense of self,’’ a theme that included loss of identity, family disruption, and/or loss of valued activities. Individuals sought to adapt their sense of self by seeking external support, by restoring normality, and/or through positive reflection. Despite the adapted self that emerged, most individuals continued to experience impairments. While young stroke survivors adapt to their illness over time, they continue to experience impairments and disruptions in their personal and work lives.Aholistic model of rehabilitation that helps individuals regain the capacity for everyday activities related to work, family life, and leisure can begin to address the emotional ramifications of diseases such as stroke, restore wellness, and work towards minimizing the burden felt by family caregivers and children
The Real (Social) Experience of Monetary Policy
This paper takes a socio-economic approach to considering money in relation to real experience, focusing on the real effects of monetary policy. While most of the economics literature focuses on interest-rate setting as the core tool of monetary policy, we focus here instead on signalling by the central bank as a mechanism for influencing expectations and behaviour in conditions of uncertainty. This involves addressing the social-conventional expectations among different groups (a mechanism for dealing with uncertainty) applied to their particular ways of framing the real and financial sectors. Actual credit conditions faced by borrowers in turn are the outcome of the conventional view among banks as a result of their framing and the influence of central bank signalling. These relations between central banks, banks and the non-bank public in turn normally rest on long-established relations of trust. We consider the real effects of monetary policy in circumstances where trust has broken down
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